abstract：:Penicillium polonicum MCCC3A00951 is a fungus with influenza neuraminidase (NA) inhibition activity derived from a sediment of the mangrove forest of Zhangjiangkou in Fujian province, China. Chemical investigation on an ethyl acetate extract of its fermentation led to the isolation of a new compound, 7-hydroxy-3,10-de...

journal_title：Natural product research

authors： Liu SZ,He FM,Bin YL,Li CF,Xie BY,Tang XX,Qiu YK

更新日期：2020-09-14 00:00:00

abstract：:Leaves of Kalanchoe pinnata are used worldwide for healing skin wounds. This study aimed to develop and compare two creams containing a leaf aqueous extract of K. pinnata (KP; 6%) and its major flavonoid [quercetin 3-O-α-L-arabinopyranosyl-(1→2)-α-L-rhamnopyranoside] (0.15%). Both creams were topically evaluated in a ...

journal_title：Natural product research

authors： Coutinho MAS,Casanova LM,Nascimento LBDS,Leal D,Palmero C,Toma HK,Dos Santos EP,Nasciutti LE,Costa SS

更新日期：2020-09-14 00:00:00

abstract：:A new phenylpropanoid allopyranoside (1) and a new indolinone alkaloid (2) were isolated from the rhizomes of Actaea dahurica (syn. Cimicifuga dahurica). The structures of those two compounds were deduced as cimicifugaside F (1) and 3E,11E-(3-methyl-2-butenylidene acid)-2-indolinone-1-O-β-d-glucopyranoside (2) by deta...

journal_title：Natural product research

authors： Ma SJ,Li HB,Shao JR,Pang QQ,Li T,Yao XS,Yu Y

更新日期：2020-09-11 00:00:00

abstract：:The aim of this study is to estimate the nutritive values, metabolites of Hass and Reed Avocado cultivars and evaluate their antimicrobial and anticancer activities. Hass was rich in water soluble vitamins, iron and calcium while, Reed contains more fat soluble vitamins. Benzaldehyde and butyl phenol derivatives were ...

journal_title：Natural product research

authors： Younis IY,Hifnawy MS,El-Hawary SS,El Bishbishy MH,Elateek SY

更新日期：2020-09-11 00:00:00

abstract：:Two new compounds, identified as 3-(2-hydroxybenzyl)-6,8-dimethoxy-4H-chromen-4-one (1), named oleracone J and 3-(2-hydroxybenzyl)-6,8-dimethoxychroman-4-one (2), named oleracone K, were isolated from Portulaca oleracea L., and the structures of them were determined by spectroscopy, including one-dimensional and two-d...

journal_title：Natural product research

authors： Duan Y,Ying Z,Zhang M,Ying X,Yang G

更新日期：2020-09-03 00:00:00

abstract：:Immature dendritic cells (iDCs) play very important roles in the pathological process of rheumatoid arthritis (RA). Therefore, it is urgent to search for natural products with antiproliferative activity on iDCs for anti-RA drug discovery. Erycibe schmidtii, a traditional Chinese medicine, has been used to treat RA in ...

journal_title：Natural product research

authors： Ren W,Wang Y,He Q,Zhou Y,Li C,Wang W,Leng X,Zeng T,Zou Q,Li L

更新日期：2020-09-01 00:00:00

abstract：:Artemisia annua L. is an annual Eurasian desert-steppe plant. The composition of essential oils found in Artemisia annua from Russian (Buryatian) flora was analyzed in this work using gas chromatography mass-spectrometry method. Artemisia ketone, β-selinene, caryophyllene, caryophyllene oxide, germacrene D were the ma...

journal_title：Natural product research

authors： Zhigzhitzhapova SV,Dylenova EP,Gulyaev SM,Randalova TE,Taraskin VV,Tykheev ZA,Radnaeva LD

更新日期：2020-09-01 00:00:00

abstract：:A new benzophenone huanglongmycin (HLM) D (1) and two new monomeric xanthones huanglongmycin E (2) and F (3), together with four known aromatic polyketides aloesaponarin II (4) and the previously isolated huanglongmycin A-C (5-7) were obtained from cave-derived Streptomyces sp. CB09001. The structures of 1-3 were esta...

journal_title：Natural product research

authors： Jiang L,Xiang J,Zhu S,Tang D,Gong B,Pu H,Duan Y,Huang Y

更新日期：2020-09-01 00:00:00

abstract：:In this study, phytochemical composition, antioxidant, enzyme inhibition and cytotoxic activities of methanol and dichloromethane (DCM) extracts of Bougainvillea glabra (B. glabra) flowers were investigated. Methanol extract was found to have higher total bioactive contents and UHPLC-MS analysis of methanol extract re...

journal_title：Natural product research

authors： Saleem H,Htar TT,Naidu R,Zengin G,Ahmad I,Ahemad N

更新日期：2020-09-01 00:00:00

abstract：:A new polycyclic polyprenylated acylphloroglucinol (1), nujiangefolin D, together with five known analogues (2-6), were isolated from the fruits of Garcinia nujiangensis. Compound 1 was screened by the LC-MS and LC-PDA. The structure of 1 was elucidated on the basis of extensive spectroscopic techniques including 1 D ...

journal_title：Natural product research

authors： Tang Z,Lu L,Zhou X,Shen J,Song W,Tang Y,Xia Z

更新日期：2020-09-01 00:00:00

abstract：:This work reports the phytochemical profile and insecticidal properties of Perovskia artemisioides Boiss essential oil (PAEO) collected in Baluchestan, Iran. Totally, twenty-six substances were identified with 1,8-cineole (25.81%), geranyl acetate (13.00%) and linalool (10.21%) as dominant chemical metabolites by GC-M...

journal_title：Natural product research

authors： Sadeghi Z,Alizadeh Z,Khorrami F,Norouzi S,Moridi Farimani M

更新日期：2020-08-26 00:00:00

abstract：:One new 14-membered ring cyclopeptide alkaloid, plenane A (1), along with six known compounds (2-7), was isolated from the roots of Clematis florida. Their structures were elucidated by means of NMR spectroscopic analysis and mass spectrometry. In addition, their anti- inflammatory effects on lipopolysaccharide-induce...

journal_title：Natural product research

authors： Wu Y,Zhang YF,Zhang HT,Ma XH,Yang NN,Feng SB,Zhong TH,Zhang YH

更新日期：2020-08-18 00:00:00

abstract：:Nine resorcinol derivatives including two new ones, 5-[(8Z,11Z,14Z)-nonadeca-8,11,14-trienyl] resorcinol (1) and 5-[(8Z,11Z,14E)-heptadeca-8,11,14-trienyl] resorcinol (2), were isolated from the leaves of Syzygium samarangense. The new structures were elucidated by means of extensive spectroscopic techniques including...

journal_title：Natural product research

authors： Hu YK,Wang L,Wang JH,Li MJ,Li F,Yang J,Zhao Y

更新日期：2020-08-13 00:00:00

abstract：:ABTRACT This study aims to design and synthesize a series of N-Acyl-N-(m-fluoro- benzyl)-6- amino-coumarins through the principle of active substructure stitching, which are based on the core structure of N-(m-fluoro-benzyl)-6-amino-coumarin. The structures of target compounds e1-e25 have been characterized by 1H NMR,...

journal_title：Natural product research

authors： Jin Y,Ding YH,Dong JJ,Wei Y,Hao SH,Feng BC

更新日期：2020-08-13 00:00:00

abstract：:Fusarium graminearum Schw. is associated with diseases in seeds and seedlings, mainly in maize, and causes damage to crops and food production. We determined the chemical compositions of essential oils from Pogostemon cablin (Blanco) Benth and Baccharis dracunculifolia DC., and evaluated their antioxidant and antifung...

journal_title：Natural product research

authors： Luchesi LA,Paulus D,Busso C,Frata MT,Oliveira JB

更新日期：2020-08-06 00:00:00

abstract：:Two new lanostane triterpnenoids named endertiins A and B (1 and 2) together with two known compounds as ganodecalone A (3) and ergosterol (4) have been successfully isolated from the cultivated fruit bodies of the mushroom Humphreya endertii Stey (Ganodermataceae). Their structures were elucidated by a combination of...

journal_title：Natural product research

authors： Quang DN,Long LD,Tung NQ,Thanh NN,Tham LX

更新日期：2020-08-03 00:00:00

abstract：:Mangrove plants are endowed with various biologically active compounds which have potent antibacterial and antioxidant properties. In present study, a bioactivity-guided fractionation for antibacterial and antioxidant active metabolites from the twigs of Avicennia officinalis collected from Kuala Selangor Nature Park,...

journal_title：Natural product research

authors： Assaw S,Mohd Amir MIH,Khaw TT,Bakar K,Mohd Radzi SA,Mazlan NW

更新日期：2020-08-01 00:00:00

abstract：:A facile, atom-economic synthesis of isoxazilidino withaferin, a novel hybrid of withaferin A, has been accomplished via two-step reaction of nitrone synthesis followed by nitrone 1,3-dipolar cycloaddition. The reaction is highly chemoselective (preferential reaction only on one of the two double bonds present on with...

journal_title：Natural product research

authors： Mandal R,Singh M,Krishnan AAV,Dahat YH,Bharitkar YP,Ravichandiran V,Hazra A

更新日期：2020-08-01 00:00:00

abstract：:In Brazilian folk medicine, Protium heptaphyllum is used to treat inflammatory conditions and to hasten wound repair. This paper aims to investigate the chemical composition and the in vitro antibacterial effects of the essential oils (EOs) obtained from P. heptaphyllum leaves and ripe and unripe fruits against a repr...

journal_title：Natural product research

authors： Cabral RSC,Alves CCF,Batista HRF,Sousa WC,Abrahão IS,Crotti AEM,Santiago MB,Martins CHG,Miranda MLD

更新日期：2020-08-01 00:00:00

abstract：:Phytochemical reinvestigation on the whole plants of Derris laxiflora Benth. afforded two new diprenylated flavanones, derriflavanones B and C (1-2), together with thirty-two known compounds, including sixteen flavonoids (3-18), eleven aromatic compounds (19-29), and five chlorophylls (30-34). All known compounds were...

journal_title：Natural product research

authors： Huang HC,Chien SC,Kuo CC,Wu MD,Cheng MJ,Chen JJ,Chiu HL,Kuo YH

更新日期：2020-08-01 00:00:00

abstract：:The Nigerian and South African varieties of Siphonochilus aethiopicus were examined for their phytochemical constituents. The ethyl acetate extract of the rhizomes of the South African variety yielded a novel diarylheptanoid, 2,3-diacetoxy-7-(3'',4''-dihydroxy-5''-methoxyphenyl)-1-(4'-hydroxy-3'-methoxyphenyl)-5-hepte...

journal_title：Natural product research

authors： Igoli NP,Al-Tannak NF,Ezenyi IC,Gray AI,Igoli JO

更新日期：2020-07-27 00:00:00

abstract：:Five flavonoids were isolated from the ethyl acetate fraction of leaves of Sophora secundiflora; formononetin (1), 5-hydroxy-4'-methoxyflavone (2), genistein (3), 5-hydroxy-8-(1-hydroxy-1-methyl-ethyl)-2-(4-hydroxyphenyl)-4H-furo-[2, 3-h]-chromen-4-one (4) and ononin (5). Additionally, LC-ESI-MS/MS analysis of the eth...

journal_title：Natural product research

authors： Aly SH,Elissawy AM,Fayez AM,Eldahshan OA,Elshanawany MA,Singab ANB

更新日期：2020-07-22 00:00:00

abstract：:Hechtia glomerata, a Mexican medicinal plant employed against bacterial infections and as food, is taxonomically related to the genus Tillandsia which has anticancer activity. Organic and aqueous extracts of H. glomerata leaves were prepared and tested for cytotoxic and antibacterial activity. UPLC-QTOF-MS analysis de...

journal_title：Natural product research

authors： Stefani T,Morales-San Claudio PDC,Rios MY,Aguilar-Guadarrama AB,González-Maya L,Sánchez-Carranza JN,González-Ferrara M,Camacho-Corona MDR

更新日期：2020-07-16 00:00:00

abstract：:In the course of our efforts to search new secondary metabolites from marine-derived fungi, one new hexylitaconic acid derivative, 3-(5-methoxycarbonylpentyl)-4-methylfuran-2,5-dione (1), and two dimeric analogues asperwelwinates A and B (2 and 3), together with ten known compounds, asperitaconic acid C (4), kotanin (...

journal_title：Natural product research

authors： Han J,Yang N,Wei S,Jia J,Lin R,Li J,Bi H,Song F,Xu X

更新日期：2020-07-15 00:00:00

abstract：:Natural products, especially plants, have been investigated as sources of new substances with antimicrobial properties. In this context, the Myrcia genus is extensively researched for presenting such activities. This work aims to evaluate the antifungal, antibacterial, and antioxidant properties of extracts and fracti...

journal_title：Natural product research

authors： Gatto LJ,Veiga A,Gribner C,Moura PF,Rech KS,Murakami FS,Dias JFG,Miguel OG,Miguel MD

更新日期：2020-07-13 00:00:00

abstract：:Present research reports the molecular docking analysis of 2019-nCoV inhibition by antiviral compounds from marine natural resources. For this study, the structure of ligand (antiviral compound) and 2019-nCoV main protease (Mpro) was received from the databases of PubChem and Protein Data Bank (PDB), respectively. Mol...

journal_title：Natural product research

authors： Vijayaraj R,Altaff K,Rosita AS,Ramadevi S,Revathy J

更新日期：2020-07-09 00:00:00

abstract：:As part of continuing our research on diverse C-7 derivatives of camptothecin (CPT), 16 CPT derivatives bearing piperazinyl-thiourea chemical scaffold and different substituent groups have been designed, synthesized and evaluated in vitro for cytotoxicity against five tumor cell lines (A-549, MDA-MB-231, MCF-7, KB and...

journal_title：Natural product research

authors： Song ZL,Yang GZ,Li JC,Liu YQ,Yang CJ,Goto M,Zhang ZJ,Morris-Natschke SL,Liu H,Lee KH

更新日期：2020-07-01 00:00:00

abstract：:A new triterpenoid glucoside, leuctriterpencoside (1), along with two known compounds (2-3) were isolated from Leucas zeylanica. The structure of the new compound was elucidated using comprehensive spectroscopic methods. Compound 1 showed significant inhibitory activity against α-glucosidase (IC50 value of 0.85 ± 0.12...

journal_title：Natural product research

authors： Chen GY,Zhang B,Zhao T,Nidhal N,Jia-Li W,Zhou XM,Chun-Yan D

更新日期：2020-07-01 00:00:00

abstract：:Six new compounds, including three terpenoids (1-3) and three lignans (4-6), were isolated from the 95% EtOH extract of the twigs of Tripterygium hypoglaucum. Their structures were determined on the basis of extensive spectroscopic analysis. 9'-O-benzoyl-lariciresinol (4) showed weak cytotoxicity against HepG2/Adr cel...

journal_title：Natural product research

authors： Zheng H,Wang L,Yang T,Liu D,Li HM,Chen XQ,Li RT

更新日期：2020-07-01 00:00:00

abstract：:A total of 25 compounds including terpenoids, flavonoids, biflavonoids and ginkgolic acids were identified and quantified with a reliable, simple, and simultaneous method from Ginkgo leaves, seed coats and embryoids with different tree ages (approximately identified as 25, 500, 1000 and 2000 years). Leaves had the hig...

journal_title：Natural product research

authors： Chen X,Zhong W,Shu C,Yang H,Li E

更新日期：2020-07-01 00:00:00

abstract：:(+) Benzomalvins E (1) and (-) Benzomalvins E (2), a pair of epimeric derivatives, together with three known benzomalvins (3-5), were isolated from solid cultures of a interrhizospheric fungus Penicillium sp. SYPF 8411. The planar structure of (+) Benzomalvins E (1) has been previously reported. While, the absolute co...

journal_title：Natural product research

authors： Feng QM,Feng Y,Zhang TY,Wang HF,Zhang MY,Wu YY,Chen G,Zhang YX,Pei YH

更新日期：2020-07-01 00:00:00

abstract：:Three flavonoid compounds were isolated from the roots of medicinal plant Tadehagi triquetrum (L.) H.Ohashi, also known as Desmodium triquetrum (Fabaceae). On the basis of the chemical and spectral analysis, the compounds were identified as baicalein (Flavone), naringin and neohesperidin (Flavonone). To the best of ou...

journal_title：Natural product research

authors： Vedpal,Jayaram U,Wadhwani A,Dhanabal SP

更新日期：2020-07-01 00:00:00

abstract：:A new cholestane-type steroidal glycoside, solamyriaside A (1), was isolated from the fruits of Solanum myriacanthum Dunal (Solanaceae), along with two known steroidal glycosides, namely, solaviaside A (2) and aculeatiside A (3), and three known steroidal alkaloid glycosides, namely, solamargine (4), khasianine (5) an...

journal_title：Natural product research

authors： Ono M,Shimode M,Tsutsumi S,Yasuda S,Okawa M,Kinjo J,Miyashita H,Ikeda T,Yoshimitsu H,Nohara T

更新日期：2020-06-19 00:00:00

abstract：:Two new glycerol esters, (S)-2-hydroxy-3-(octanoyloxy)propyl tetracosanoate (1) and (S)-3-(((S)-11-acetoxy octadecanoyl)oxy)propane-1,2-diyl diacetate (2), and eight known compounds, docosanedioic acid (3), 2,5-dimethylnonadecane (4), lupeol (5), stigmasterol (6), β-sitosterol (7), heptadecanoic acid (8), hexanedioic ...

journal_title：Natural product research

authors： Forestrania RC,Anaya-Eugenio GD,Acuña UM,Ren Y,Elya B,de Blanco EC

更新日期：2020-06-12 00:00:00

abstract：:Two triterpenes (14S,17S,20S,24R)-25-hydroxy-14,17-cyclo-20,24-epoxy-malabarican-3-one (CEM, 1a) and (14S,17S,20S,24R)-20,24,25-trihydroxy-14,17-cyclomalabarican-3-one (CM, 2a) with a cyclobutane ring were reported, which have the same NMR data as ocotillone (1b) and gardaubryone C (2b), respectively. An incorrect str...

journal_title：Natural product research

authors： Duan ZK,Lv TM,Song GS,Wang YX,Lin B,Huang XX

更新日期：2020-06-11 00:00:00

abstract：:Two new benzoic acid derivatives, named methyl(S)-3-hydroxy-4-(2- hydroxy -6-methylheptan-2-yl)benzoate (1) and 2-hydroxy-3-(6- hydroxy-6-methylhept-1-en-2-yl)benzoic acid (2), were isolated from the ethanol extract of an endophytic fungus Aspergillus versicolor derived from the medicinal plant Euphorbia royleana. The...

journal_title：Natural product research

authors： Ye Y,Chen Y,Hou Y,Yu H,Zhu L,Sun Y,Zhou M,Chen Y,Dong M

更新日期：2020-06-11 00:00:00

abstract：:A new chromone glycoside, 8-O-β-D-Glucopyranosyl-2-methylchromone (1), together with eight known compounds (2-9) were isolated from the Tibetan medicine plant of Swertia punicea. All compounds of this plant were reported for the first time. The structures of these metabolites were elucidated by analysis of their HR-ES...

journal_title：Natural product research

authors： Mou LY,Wei M,Wu HY,Hu LJ,Li JL,Li GP

更新日期：2020-06-11 00:00:00

abstract：:Santolina insularis is a Sardinian endemism that is widely used in traditional medicine. The essential oil was obtained with a yield of 2.7% and is mainly characterized by β-phellandrene (22.6%), myrcene (11.4%) and artemisia ketone (7.6%). The oil significantly reduced NO production without affecting macrophages viab...

journal_title：Natural product research

authors： Alves-Silva JM,Piras A,Porcedda S,Falconieri D,Maxia A,Gonçalves MJ,Cruz MT,Salgueiro L

更新日期：2020-06-04 00:00:00

abstract：:Chemical investigation of Penthorum chinense resulted in the isolation of two neolignans (1 and 2) together with two known compounds (3 and 4). The structures of compounds 1 and 2 were determined by interpretation of spectroscopic data, and absolute configurations were made based on electronic circular dichroism (ECD)...

journal_title：Natural product research

authors： Huang D,Dong Z,Sun L,Chen W,Sun L

更新日期：2020-06-01 00:00:00

abstract：:The chemical analyses of ethyl acetate-methanol (EtOAc-MeOH) extract of muricid gastropod mollusk, Chicoreus ramosus from the southeastern coast of Indian peninsular led to the identification of unprecedented cembrane-type diterpenoid, which was characterized as (3E, 6E, 10E)-8a-butoxy-17(15→14), 20(12→11)-bis-abeo-ce...

journal_title：Natural product research

authors： Chakraborty K,Salas S,Joy M

更新日期：2020-06-01 00:00:00